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KMID : 1149120190160020076
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Journal of the Korean Society for Psoriasis
2019 Volume.16 No. 2 p.76 ~ p.79
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A Case of Psoriasiform Skin Lesion after Dupilumab Treatment in a Patient with Atopic Dermatitis
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Lee Keon-Hee
Suh Hyun-Yi
Lee Woo-Jin
Chang Sung-Eun
Lee Mi-Woo
Choi Jee-Ho
Won Chong-Hyun
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Abstract
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Dupilumab is a fully human monoclonal antibody targeting the shared alpha subunit of IL (Interleukin)-4 and IL-13 receptors, which play an important role in the T-helper (Th)2-mediated inflammatory response in atopic dermatitis. Psoriasis is a chronic inflammatory disease driven by Th1, Th17 and Th22 Tcell subsets. IL-4, a negative Th1 and Th17 cell regulator, can inhibit the IL-1￥a and IL-6 secretion and modulate the dendritic cell phenotype suppressing the IL-23 production in psoriasis. A 43-year-old woman presented for erythematous scaly papules and plaques on her face and neck, which had appeared 3 months ago. She had been treated with Dupilumab for atopic dermatitis during the last 6 months and had no previous history of psoriasis. The patient was diagnosed with psoriasiform skin lesion and began to treat using topical tacrolimus ointment. Herein, we report a rare case of psoriasiform skin lesion after dupilumab treatment.
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KEYWORD
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Atopic dermatitis, Dupilumab, Psoriasiform eruption
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